Qantas will become the first airline in the world to operate a non-stop route between Australia and Las Vegas.
The announcement comes just hours after Qantas unveiled the biggest overhaul of its Frequent Flyer status program in history.
More than 250,000 Australians visit Las Vegas each year.
The new seasonal service will run from December 2026 to March 2027.
It will save customers up to five hours in travel time by eliminating the need for connections through another US city.
The route will operate on a Boeing 787 Dreamliner aircraft three times per week on Tuesday, Thursday and Sunday, departing at 9pm and arriving in Las Vegas at 3.55pm.
The flight time is roughly 13 hours and 55 minutes with economy return fares starting from $1099.
The service will operate during some of the city's biggest global events and expos including Consumer Electronics Show and Rugby League Las Vegas.
President of the Las Vegas Convention and Visitors Authority, Steve Hill, said Qantas's new nonstop service from Sydney was a testament to the strength of the Australian market for Las Vegas.
"Australia has consistently ranked as our second-largest overseas market and our top international market without a nonstop flight," he said.
Australian Bureau of Statistics data released on February 12 found Australians are bypassing the US in favour of closer, simpler options in Asia and New Zealand with travel to the US falling by around three per cent in 2025.